Optimizer_from

	Back-translate a protein sequence using the most frequent synonymous codons from a reference codon usage table
This is a simplified version of the OPTIMIZER web server that Back-translate a protein sequence using the most frequent synonymous codons from a reference codon usage table. The method used corresponds to the 'one amino acid - one codon' of the OPTIMIZER server and the universal genetic code is used. Created by Santi Garcia-Vallvé. May 2024
Insert a protein sequence: See an example of the spike protein from the SARS-CoV-2
Insert a codon usage reference table (by defaul the human codon usage): TTT (171) TCT (147) TAT (124) TGT (99) TTC (203) TCC (172) TAC (158) TGC (119) TTA (73) TCA (118) TAA (0) TGA (0) TTG (125) TCG (45) TAG (0) TGG (122) CTT (127) CCT (175) CAT (104) CGT (47) CTC (187) CCC (197) CAC (147) CGC (107) CTA (69) CCA (170) CAA (121) CGA (63) CTG (392) CCG (69) CAG (343) CGG (115) ATT (165) ACT (131) AAT (174) AGT (121) ATC (218) ACC (192) AAC (199) AGC (191) ATA (71) ACA (150) AAA (248) AGA (113) ATG (221) ACG (63) AAG (331) AGG (110) GTT (111) GCT (185) GAT (230) GGT (112) GTC (146) GCC (282) GAC (262) GGC (230) GTA (72) GCA (160) GAA (301) GGA (168) GTG (288) GCG (74) GAG (404) GGG (160)
If you use this server please cite the following article Puigbò P, Guzmán E, Romeu A, Garcia-Vallvé S. OPTIMIZER: a web server for optimizing the codon usage of DNA sequences. Nucleic Acids Res. 2007 Jul;35(Web Server issue):W126-31. doi: 10.1093/nar/gkm219.

Back-translate a protein sequence using the most frequent synonymous codons from a reference codon usage table